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Gadolinium-Enhanced Portable Ultra-Low-Field MRI for Evaluating Various Intracranial Pathologies.

Habeeb F Kazimuddin1, Ajay Pathakamuri1, June Yi2

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Portable ultra-low-field (pULF) MRI can show gadolinium contrast enhancement in various brain conditions, matching 3-tesla MRI results. This demonstrates pULF-MRI

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Area of Science:

  • Medical Imaging
  • Neurology
  • Magnetic Resonance Imaging

Background:

  • Portable ultra-low-field (pULF) MRI scanners are increasing MRI accessibility.
  • The diagnostic value of contrast-enhanced pULF-MRI is not well understood.

Purpose of the Study:

  • To evaluate pULF-MRI's ability to detect diagnostically useful contrast enhancement patterns.
  • To compare pULF-MRI contrast enhancement with 3-tesla (3T) MRI findings.

Main Methods:

  • Five neurological cases (meningiomas, infection, oligodendroglioma, subdural hematoma) were studied.
  • Contrast agents (gadoteridol, gadobutrol, gadopiclenol) were administered.
  • Enhancement patterns on pULF-MRI were qualitatively compared to matched 3T MRI slices.

Main Results:

  • Post-contrast enhancement was visible on pULF-MRI in all cases.
  • pULF-MRI findings corresponded with 3T MRI results.
  • Limitations included calcified, small, or heterogeneous enhancing tissues due to factors like partial volume effects and SNR.

Conclusions:

  • pULF-MRI can depict diagnostically meaningful gadolinium enhancement across diverse pathologies.
  • Contrast-enhanced pULF-MRI shows feasibility and potential clinical utility.
  • Further validation of use cases can improve neurological care where standard MRI access is limited.