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Related Concept Videos

Ionic Radii03:10

Ionic Radii

33.4K
Ionic radius is the measure used to describe the size of an ion. A cation always has fewer electrons and the same number of protons as the parent atom; it is smaller than the atom from which it is derived. For example, the covalent radius of an aluminum atom (1s22s22p63s23p1) is 118 pm, whereas the ionic radius of an Al3+ (1s22s22p6) is 68 pm. As electrons are removed from the outer valence shell, the remaining core electrons occupying smaller shells experience a greater effective nuclear...
33.4K
Ionic Bonds00:42

Ionic Bonds

129.6K
Overview
When atoms gain or lose electrons to achieve a more stable electron configuration they form ions. Ionic bonds are electrostatic attractions between ions with opposite charges. Ionic compounds are rigid and brittle when solid and may dissociate into their constituent ions in water. Covalent compounds, by contrast, remain intact unless a chemical reaction breaks them.
Opposing Charges Hold Ions Together in Ionic Compounds
Ionic bonds are reversible electrostatic interactions between ions...
129.6K
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

20.0K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
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Solubility of Ionic Compounds02:55

Solubility of Ionic Compounds

68.1K
Solubility is the measure of the maximum amount of solute that can be dissolved in a given quantity of solvent at a given temperature and pressure. Solubility is usually measured in molarity (M) or moles per liter (mol/L). A compound is termed soluble if it dissolves in water.
68.1K
Ionic Crystal Structures02:42

Ionic Crystal Structures

16.9K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
16.9K
Ionic Compounds: Formulas and Nomenclature03:34

Ionic Compounds: Formulas and Nomenclature

86.4K
An element composed of atoms that readily lose electrons (a metal) can react with an element composed of atoms that readily gain electrons (a nonmetal) to produce ions through complete electron transfer. The compound formed by this transfer is stabilized by the electrostatic attractions (ionic bonds) between the oppositely charged ions.
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Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids
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Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids

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Protein stability analysis in ionic liquids by 19F NMR.

Kai Cheng1, Qiong Wu1, Ling Jiang1

  • 1Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Collaborative Innovation Center of Chemistry for Life Sciences, Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences, Wuhan, 430071, Hubei, China.

Analytical and Bioanalytical Chemistry
|April 26, 2019
PubMed
Summary

Ionic liquids destabilize proteins, impacting biological reactions. Fluorine-19 NMR (¹⁹F NMR) quantifies this effect, offering a new method for studying protein stability and interactions in ionic liquids.

Keywords:
19F NMRIonic liquidsProtein stability quantification

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Area of Science:

  • Biochemistry
  • Chemical Engineering
  • Materials Science

Background:

  • Ionic liquids are recognized as green solvents for biological applications.
  • Understanding ionic liquid effects on protein stability is vital for optimizing enzymatic reactions and protein storage.
  • Quantitative thermodynamic data on protein stability in ionic liquids remains limited.

Purpose of the Study:

  • To quantitatively measure the equilibrium thermodynamics of protein stability in the ionic liquid [C4-mim]Br.
  • To explore the utility of Fluorine-19 Nuclear Magnetic Resonance (¹⁹F NMR) for this purpose.

Main Methods:

  • Utilized Fluorine-19 Nuclear Magnetic Resonance (¹⁹F NMR) spectroscopy.
  • Measured equilibrium thermodynamics of protein stability in [C4-mim]Br ionic liquid.

Main Results:

  • Proteins exhibit significant destabilization in [C4-mim]Br ionic liquids.
  • ¹⁹F NMR proved to be a simple and effective method for assessing protein stability thermodynamics.
  • The technique shows potential for studying protein-protein interactions in ionic liquids.

Conclusions:

  • Ionic liquids, specifically [C4-mim]Br, can significantly destabilize proteins.
  • ¹⁹F NMR is a valuable tool for thermodynamic analysis of protein stability in ionic liquids.
  • This methodology can advance the study of biomolecular interactions within ionic liquid environments.