Related Experiment Video
Updated: Jan 25, 2026
26:41
Perspectives on Neuroscience
Published on: July 31, 2007
5.3K
Molecular Imaging and Tracking Stem Cells in Neurosciences.
Nora Sandu1, Thomas Rosemann1, Bernhard Schaller2
1Department of Primary Care, University of Zurich, Zürich, Switzerland.
Methods in Molecular Biology (Clifton, N.J.)
|April 26, 2019
Summary
Molecular imaging techniques enable noninvasive tracking of stem cells in neurological disease research. This allows for better monitoring of cell survival, migration, and differentiation, aiding clinical translation.
Area of Science:
- Regenerative Medicine
- Neuroscience
- Medical Imaging
Background:
- Stem cell transplantation shows promise for neurological diseases but faces challenges in clinical translation.
- Difficulty in detecting, localizing, and examining transplanted stem cells in vivo hinders clinical application.
- Current limitations prevent the full potential of stem cell therapy from being realized in patients.
Purpose of the Study:
- To review and compare molecular imaging techniques for tracking stem cells in neurological disease research.
- To highlight the role of noninvasive imaging in monitoring stem cell survival, migration, and differentiation.
- To discuss the potential of these imaging methods for future therapeutic applications.
Main Methods:
- Summary and comparison of various molecular imaging techniques for stem cell labeling and tracking.
- Focus on methods applicable to both animal models and clinical settings.
- Evaluation of techniques for noninvasive, quantitative, and repeated monitoring of stem cells.
Main Results:
- Molecular imaging offers advanced capabilities for noninvasive, quantitative tracking of stem cells.
- These techniques allow real-time monitoring of stem cell fate from transplantation to differentiation.
- Successful application in animal models provides a foundation for clinical translation.
Conclusions:
- Molecular imaging is crucial for overcoming current barriers in stem cell transplantation for neurological disorders.
- Noninvasive tracking facilitates the assessment of stem cell engraftment and therapeutic efficacy.
- Advancements in imaging pave the way for improved clinical translation and novel therapeutic strategies.
More Related Videos
09:34A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
Published on: October 25, 2018
7.1K
10:55Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations
Published on: December 16, 2017
9.1K
Related Concept Videos
01:33Adult Stem Cells
33.4K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.4K
00:58Embryonic Stem Cells
32.1K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.1K
01:13Induced Pluripotent Stem Cells
27.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K
01:27Molecular Factors Affecting Cell Division
3.9K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.9K
02:00Molecular Models
43.6K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.6K
02:54Molecular and Ionic Solids
20.0K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.0K