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Related Concept Videos

Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Three-Dimensional Reconstruction of Orbital Fractures
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Orbital AL amyloid.

Tiffany Michelle Chan1, Claudia Maria Prospero Ponce2, Richard Cutler Allen3,4

  • 1College of Medicine, Texas A&M University,Bryan, Texas, USA.

Orbit (Amsterdam, Netherlands)
|April 26, 2019
PubMed
Summary
This summary is machine-generated.

Ocular adnexal amyloidosis and lymphoma are rare conditions that mimic common inflammatory diseases. Early histopathologic analysis is crucial for diagnosing these rare orbital tumors, preventing delayed treatment.

Keywords:
Amyloidosisfacial painlymphomaophthalmoplegiaosteomyelitis

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Ocular adnexal amyloidosis and lymphoma are rare conditions.
  • Their symptoms can mimic common inflammatory conditions like autoimmune disease or infection.
  • This can lead to delayed diagnosis and treatment.

Observation:

  • A patient presented with persistent facial and tooth pain, along with ophthalmoplegia.
  • These symptoms were indicative of a rare orbital condition.

Findings:

  • The case involved orbital AL amyloidosis co-occurring with localized lymphoma.
  • The patient experienced intractable dental pain and progressed to bilateral complete ophthalmoplegia.

Implications:

  • This case highlights the importance of considering rare conditions in differential diagnoses.
  • Prompt histopathologic analysis of biopsy specimens is essential for accurate diagnosis.
  • Early diagnosis and treatment are critical for managing ocular adnexal amyloidosis and lymphoma.