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Thyroid function following breast cancer chemotherapy: A systematic review
Keywan Mortezaee1, Amirhossein Ahmadi2, Hamed Haghi-Aminjan3
1Department of Anatomy, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Journal of Cellular Biochemistry
|April 26, 2019
Summary
Breast cancer chemotherapy can lower thyroid hormone levels, including triiodothyronine (T3) and thyroxin (T4). Further research is needed to clarify changes in thyroid-stimulating hormone (TSH) following treatment.
Area of Science:
- Endocrinology
- Oncology
- Pharmacology
Background:
- Chemotherapy is a primary treatment for breast cancer.
- Chemotherapeutic agents can induce thyroid dysfunction.
- Systematic review of thyroid function post-chemotherapy in breast cancer patients.
Purpose of the Study:
- To investigate thyroid toxicities from various chemotherapy regimens in breast cancer patients.
- To summarize existing data on thyroid function after breast cancer chemotherapy.
Main Methods:
- Systematic literature search conducted in Scopus, Embase, PubMed, and Web of Science.
- Adherence to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
- Inclusion of eight eligible studies based on predefined criteria.
Main Results:
- Decreased levels of triiodothyronine (T3), free T3 (FT3), thyroxin (T4), and free T4 (FT4) were observed in most cases.
- Thyroid-stimulating hormone (TSH) level alterations were unclear post-chemotherapy.
- Chemotherapy regimens commonly used for breast cancer impact thyroid hormone levels.
Conclusions:
- Thyroid function is affected by chemotherapy in breast cancer patients.
- Changes in thyroid-stimulating hormone (TSH) levels require further investigation.
- Understanding chemotherapy-induced thyroid dysfunction is crucial for patient management.
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