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Pathophysiology and treatment of hoarding disorder

Tomohiro Nakao1, Shigenobu Kanba1

  • 1Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Psychiatry and Clinical Neurosciences
|April 26, 2019
PubMed

Insights

Hoarding disorder (HD), a distinct condition from obsessive-compulsive disorder (OCD), presents unique clinical and neurobiological features. Cognitive behavioral therapy shows promise for managing HD symptoms.

Area of Science:

  • Psychiatry
  • Neuroscience
  • Psychology

Background:

  • Hoarding disorder (HD) is now classified under Obsessive-Compulsive and Related Disorders in DSM-5.
  • HD is characterized by difficulty discarding possessions, leading to cluttered living spaces and impaired function.
  • Recent research highlights distinct clinical and neurobiological differences between HD and other obsessive-compulsive disorder (OCD) subtypes.

Purpose of the Study:

  • To review the pathophysiology of hoarding disorder.
  • To discuss current and emerging treatment strategies for hoarding disorder.

Main Methods:

  • Literature review of clinical characteristics.
  • Review of neuroimaging studies comparing HD and non-HD OCD patients.
  • Analysis of current treatment approaches, focusing on cognitive behavioral therapy.

Main Results:

  • Hoarding disorder exhibits unique onset, course, insight, and treatment response patterns compared to other OCD subtypes.
  • Neuroimaging studies reveal specific structural and functional brain changes in individuals with hoarding symptoms.
  • Cognitive behavioral therapy (CBT) demonstrates efficacy in treating HD.

Conclusions:

  • Hoarding disorder is a distinct clinical entity requiring tailored treatment approaches.
  • Further research into HD pathophysiology is crucial for developing standardized treatments.
  • Cognitive behavioral therapy is a key intervention for managing hoarding disorder.

Keywords:
DSM-5hoarding disorderobsessive-compulsive and related disorderspathophysiologytreatment

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