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Normal Growth despite Combined Pituitary Hormone Deficiency
Mohamed El Kholy1, Heba Elsedfy1, Laurence Perin2
1Department of Pediatrics, Ain Shams University, Cairo, Egypt.
Hormone Research in Paediatrics
|April 26, 2019
Summary
Normal growth without sufficient growth hormone (GH) was observed in a patient with panhypopituitarism. A HESX1 mutation was identified, suggesting a potential mechanism for growth in the absence of GH, possibly influenced by other genetic factors.
Area of Science:
- Pediatric Endocrinology
- Genetics
- Molecular Biology
Background:
- The paradox of normal growth despite low growth hormone (GH) is observed in certain conditions.
- Potential causes include GH variants, prolactin, insulin, insulin-like growth factors (IGFs), or unknown factors.
- The study aimed to elucidate the mechanism of growth in the absence of GH.
Keywords:
Combined pituitary hormone deficiencyGrowthIGF/IGFBP-3 molar ratioInsulin-like growth factorsMore Related Videos
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