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Circbank: a comprehensive database for circRNA with standard nomenclature
RNA Biology
|April 27, 2019
Summary
A new database, CircBank, offers a standardized naming system for circular RNAs (circRNAs) and compiles crucial data. This resource aids researchers in exploring circRNA functions and regulation.
Area of Science:
- Molecular Biology
- Genomics
- Bioinformatics
Background:
- Circular RNAs (circRNAs) are a novel class of regulatory molecules formed by back-splicing.
- circRNAs play roles in gene expression regulation at transcriptional and post-transcriptional levels.
- A lack of standardized nomenclature hinders circRNA research.
Purpose of the Study:
- To introduce CircBank, a comprehensive database for human circRNAs.
- To implement a novel naming system for circRNAs based on their host genes.
- To consolidate diverse circRNA features for enhanced research accessibility.
Main Methods:
- Development of a novel circRNA naming convention.
- Creation of a centralized database (CircBank) for human circRNAs.
- Integration of features including miRNA binding sites, conservation, m6A modification, mutations, and protein-coding potential.
Main Results:
- CircBank provides a standardized nomenclature for circRNAs.
- The database integrates six key features for each circRNA.
- Users can query, browse, and download circRNA data based on various criteria.
Conclusions:
- CircBank serves as a valuable resource for the scientific community.
- The database facilitates research into the function and regulation of circRNAs.
- Standardized naming and comprehensive data promote further circRNA studies.
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