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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Differentially expressed circulating miRNAs in postmenopausal osteoporosis: a meta-analysis

Elif Pala1, Tuba Denkçeken2

  • 1Department of Medical Biology, Faculty of Medicine, SANKO University, Gaziantep, Turkey epala@sanko.edu.tr.

Bioscience Reports
|April 27, 2019
PubMed

Insights

Circulating microRNAs (miRNAs) show promise for diagnosing postmenopausal osteoporosis (PMO). This study identified hsa-miR-133a-3p as a key biomarker, potentially useful for non-invasive diagnosis and treatment of PMO.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biomarker Discovery

Background:

  • MicroRNAs (miRNAs) are critical in postmenopausal osteoporosis (PMO) pathogenesis.
  • Increasing research focuses on miRNAs as diagnostic markers for PMO.
  • Identifying specific miRNAs can aid in early detection and management of PMO.

Purpose of the Study:

  • To identify key microRNAs (miRNAs) in postmenopausal osteoporosis (PMO) as potential biomarkers.
  • To evaluate the diagnostic value of specific miRNAs in PMO.
  • To explore the therapeutic potential of identified miRNAs in PMO.

Main Methods:

  • Systematic literature search of PubMed, Web of Science, Embase, and Cochrane Library.
  • Meta-analysis using robust rank aggregation (RRA) on 16 miRNA expression studies (327 PMO patients, 328 controls).
  • Bioinformatics analysis for target gene prediction and pathway enrichment (Kyoto Encyclopedia of Genes and Genomes).

Main Results:

  • A significant meta-signature of up-regulated hsa-miR-133a-3p (P = 1.38e-03) was identified in PMO.
  • Bioinformatics analysis linked hsa-miR-133a-3p to pathways including adrenergic signaling, adherens junction, PI3K-Akt, and AMPK signaling.
  • Six hub genes (CDC42, RHOA, EGFR, VAMP2, PIK3R2, FN1) were identified, enriched in signaling and cancer pathways.

Conclusions:

  • Circulating hsa-miR-133a-3p may serve as a potential non-invasive biomarker for PMO.
  • hsa-miR-133a-3p presents a potential therapeutic target for postmenopausal osteoporosis.
  • Further research is warranted to validate hsa-miR-133a-3p as a clinical biomarker for PMO.
Keywords:
Postmenopausal osteoporosisRobust rank aggregationbiomarkercirculating miRNAsmeta-analysis

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