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Integrating Next-Generation Sequencing in the Clinical Pharmacogenomics Workflow
Efstathia Giannopoulou1, Theodora Katsila1, Christina Mitropoulou2
1Department of Pharmacy, School of Health Sciences, University of Patras, Patras, Greece.
Frontiers in Pharmacology
|April 27, 2019
Summary
Pharmacogenomics, a key to personalized medicine, uses next-generation sequencing to analyze genetic variations. This study proposes integrating this advanced sequencing into clinical workflows for better pharmacogenomic consultation.
Area of Science:
- Genomic Medicine
- Clinical Pharmacology
Background:
- Pharmacogenomics is crucial for personalized medicine, with 266 drug labels including pharmacogenomic information.
- Next-generation sequencing (NGS) provides comprehensive individual genetic profiles, vital for clinical relevance.
Purpose of the Study:
- To propose a strategy for integrating NGS into clinical pharmacogenomics workflows.
- To align NGS integration with existing guidelines for pharmacogenomic consultation.
Main Methods:
- Deep resequencing using next-generation sequencing.
- Integration into the existing clinical pharmacogenomics workflow.
- Adherence to current guidelines and recommendations.
Main Results:
- A proposed strategy for seamless NGS integration.
- Enhanced identification of pharmacogenomic biomarkers and pathogenic variants.
- Improved clinical pharmacogenomic consultation.
Conclusions:
- NGS integration offers a robust approach to clinical pharmacogenomics.
- This strategy supports the advancement of personalized medicine.
- The proposed workflow aligns with established pharmacogenomic guidelines.
Keywords:
clinical decision support toolsclinical pharmacogenomicsimplementationnext-generation sequencingworkflowMore Related Videos
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