Related Experiment Video
Updated: Jun 8, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Cost-effectiveness of genome-guided statin treatment for hypercholesterolemia
Margarita-Ioanna Koufaki1, Korina Tzerefou2, Achilleas Tyrovolas2
1University of Patras, School of Health Sciences, Department of Pharmacy, Laboratory of Pharmacogenomics and Individualized Therapy, Patras, Greece.
Abstract:
Cardiovascular disease and hypercholesterolemia present significant global health and economic burdens. While statins are the standard treatment, individual variability and toxicities necessitate personalized approaches. This narrative review (2013-2025) evaluated the economic landscape of pharmacogenomics (PGx)-guided statin therapy and factors influencing its cost-effectiveness. Out of 219 studies, only four relevant evaluations were identified, all focusing on North American (United States & Canada) cohorts and published before 2019. Most models relied on literature-based simulations and utility data, introducing significant parameter uncertainty. Nevertheless, PGx-guided strategies generally proved cost-effective or dominant, particularly at higher willingness-to-pay thresholds, such as $50,000/QALY. In conclusion, PGx-guided therapy offers a viable pathway for improving clinical outcomes and economic efficiency. However, a paucity of raw clinical data and geographic diversity currently limit its standardized adoption. Future research must leverage real-world evidence from ongoing trials to inform robust, value-based healthcare policy.
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Pharmacogenomics: Identification of New Drug Targets
Atherosclerosis III: Management
Cholesterol: Significance and Regulation
Considering cholesterol and...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...