Related Experiment Video
Updated: Jan 25, 2026
Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
Analysis of the clinical characteristics and refraction state in premature infants: a 10-year retrospective analysis
Yan Deng1, Chun-Hong Yu1, Yun-Tao Ma2
1Pediatric Ophthalmology, the Second Affiliated Hospital of Nanchang University, Nanchnag 330006, Jiangxi Province, China.
Insights
Premature infants treated for retinopathy of prematurity (ROP) show higher rates of myopia and astigmatism. These findings highlight the importance of monitoring refractive status in infants with ROP.
Area of Science:
- Ophthalmology
- Neonatology
- Pediatrics
Background:
- Retinopathy of prematurity (ROP) is a significant cause of visual impairment in premature infants.
- Understanding the long-term visual outcomes and refractive status in these infants is crucial for effective management.
Purpose of the Study:
- To investigate the visual outcomes and refractive status of premature infants with and without ROP.
- To compare outcomes between treated and untreated ROP cases.
Main Methods:
- Retrospective review of clinical records of 562 premature infants (2007-2017).
- Analysis of ROP incidence, treatment, visual outcomes, and refractive states (myopia, astigmatism).
- Correlations between refractive progression, birth weight, gestational age, and treatment methods were examined.
Main Results:
- Overall ROP incidence was 16.55%; no significant difference between sexes, but severe ROP (Stage IV-V) occurred only in males.
- Myopia and astigmatism were common, particularly in infants with ROP (48.84%).
- Infants treated for ROP showed the highest prevalence of myopic refraction (63.63%).
Conclusions:
- Refractive states differ significantly between premature and mature infants.
- Treatment for ROP is associated with an increased risk of developing myopia, astigmatism, and higher diopter values.
- These findings underscore the need for specialized ophthalmic care for premature infants, especially those with ROP.
Aim:
To report the visual outcomes and refractive status in premature infants with and without retinopathy of prematurity (ROP) who were or not treated.
Methods:
The clinical records of all premature infants with or without ROP and with or without treatment between 2007 and 2017 were retrospectively reviewed. Basic demographic data, serial changes in ROP incidence, treatment and outcomes, and the refractive states were analyzed. Correlations among myopia and astigmatism progression, birth weight, gestational age, and treatment methods were also analyzed.
Results:
A total of 562 screened premature infants (all Chinese, 1124 eyes), were recruited with a 378:184 male-to-female ratio. Birth weight did not directly influence ROP incidence. The overall ROP incidence was 16.55% (93/562 cases). The incidences in boys and girls were 16.14% (33/378 cases) and 17.39% (32/184 cases), respectively, and this difference was not significant. However, all infants with serious ROP (stage IV and V) were male. Myopia combined with astigmatism was common in premature infants with and without ROP (30.99%, 172/555 cases), and myopic refraction (including myopia and myopia combined with astigmatism) was more common in premature infants with ROP (48.84%, 42/86 cases). In the >8.00 diopter group, there were significantly more ROP infants than without ROP. Myopic refraction (including myopia and myopia combined with astigmatism) was most common in infants with ROP after treatment (63.63%, 7/11 cases).
Conclusion:
The refractive state is different between premature infants and mature infants. Those treated for ROP had a higher chance of developing myopia, astigmatism, and higher diopter.
Related Concept Videos
01:12Statistical Software for Data Analysis and Clinical Trials
03:46Qualitative Analysis
For instance, group IV...
01:23Characteristics of Life
03:40Dimensional Analysis
Conversion Factors and Dimensional Analysis
The unit...
01:35Pedigree Analysis
01:20Characteristics of Fluids