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Updated: Jan 25, 2026
Basic Research in Plasma Medicine - A Throughput Approach from Liquids to Cells
Published on: November 17, 2017
Chronic Renal Failure as a Possible Risk Factor for Allergic Reaction in Therapeutic Plasma Exchange Using Fresh
Megumi Eguchi1, Kenji Okumura2, Kazunari Torigoe1
1Division of Clinical Engineering, Department of General Internal Medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.
Patients with chronic renal failure experienced more allergic reactions during fresh frozen plasma exchange. This suggests a link between kidney disease and adverse reactions, impacting therapeutic plasma exchange safety.
Area of Science:
- Nephrology
- Immunology
- Transplantation
Background:
- Allergic reactions during therapeutic plasma exchange (TPE) using fresh frozen plasma (FFP) in patients with chronic renal failure (CRF) are not well-documented.
- CRF is a complex condition affecting multiple body systems, potentially influencing immune responses.
Purpose of the Study:
- To investigate the incidence of allergic reactions in patients with CRF undergoing TPE with FFP.
- To compare allergic reaction rates between patients with and without CRF.
Main Methods:
- Retrospective review of 62 patients undergoing TPE between January 2013 and May 2018.
- Analysis of patient data, including indication for TPE, dialysis status, and occurrence of allergic reactions.
Main Results:
- The overall incidence of allergic reactions was significantly higher in patients with CRF (57.1%) compared to those without (25.0%) (P = 0.029).
- Incidence of allergic reactions was highest in peritoneal dialysis patients (75%), followed by hemodialysis (58.8%) and preemptive kidney transplant patients (58%).
- The most common indication for TPE was desensitization/preconditioning for kidney transplant (61.3%).
Conclusions:
- CRF is associated with a significantly higher incidence of allergic reactions during TPE using FFP.
- These findings highlight a potential increased risk in CRF patients, necessitating further investigation into management strategies.
- The results suggest a relationship between the state of chronic renal failure and allergic responses to FFP during TPE.
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