Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

127.2K
Overview
127.2K
Molecular Models02:00

Molecular Models

43.6K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.6K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.6K
Overview
83.6K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.5K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.5K
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

3.9K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.9K
Humoral Immune Responses01:36

Humoral Immune Responses

83.5K
Overview
83.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cathepsin S regulates germinal center reactions and anti-tumor humoral responses.

The Journal of experimental medicine·2026
Same author

Novel energy balance tracking to support personalised AI health coaching: a real-world evaluation of the ENHANCE framework.

International journal of obesity (2005)·2026
Same author

Fetal-restricted hematopoietic progenitors arise from hemogenic endothelium in vitelline and umbilical arteries.

Nature cardiovascular research·2026
Same author

BMAL1 modulates glutamine supply to control haematopoietic stem and progenitor cell expansion.

Development (Cambridge, England)·2026
Same author

Correction: Contribution of IL-17-producing γδ T cells to the efficacy of anticancer chemotherapy.

The Journal of experimental medicine·2026
Same author

Biliary absorption of dalbavancin: A prospective monocentric protocol in liver transplant recipients (DALBATRANS).

Infectious diseases now·2026

Related Experiment Video

Updated: Jan 25, 2026

Studying Organelle Dynamics in B Cells During Immune Synapse Formation
15:39

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Published on: June 1, 2019

9.6K

New Molecular Insights into Immune Cell Development.

Ana Cumano1,2, Claire Berthault1,2, Cyrille Ramond1

  • 1Unité Lymphopoïèse, Département d'Immunologie, INSERM U1223, Institut Pasteur, 75724 Paris CEDEX 15, France; email: ana.cumano@pasteur.fr , claire.berthault@inserm.fr , pablo.pereira-esteva@pasteur.fr.

Annual Review of Immunology
|April 27, 2019
PubMed
Summary

Early immune cells, innate lymphoid cells and embryonic T cells, establish tissue protection during development. This process involves specialized progenitors that seed peripheral tissues, ensuring immune readiness and homeostasis throughout life.

Keywords:
fetal liverinnate lymphoid cellslineage commitmentlymphoid progenitorsthymus-settling progenitorstranscriptional signatures

More Related Videos

Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

15.5K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

37.1K

Related Experiment Videos

Last Updated: Jan 25, 2026

Studying Organelle Dynamics in B Cells During Immune Synapse Formation
15:39

Studying Organelle Dynamics in B Cells During Immune Synapse Formation

Published on: June 1, 2019

9.6K
Isolation of Functional Cardiac Immune Cells
07:26

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

15.5K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

37.1K

Area of Science:

  • Immunology
  • Developmental Biology

Background:

  • Innate lymphoid cells and specialized lymphocytes colonize tissues during development, aiding organogenesis and immune defense.
  • Certain lymphocyte subsets are generated exclusively during embryonic development and persist lifelong.

Purpose of the Study:

  • To elucidate the developmental pathways of early immune cell populations in peripheral tissues.
  • To understand the sequential establishment of immune functions for effective tissue seeding.

Main Methods:

  • Analysis of progenitor cell differentiation pathways.
  • Tracing the migration and colonization of immune cells in developing tissues.

Main Results:

  • Embryonic development involves unique progenitors that differentiate into innate lymphoid cells or embryonic T cells.
  • These cells lose myeloid and B cell potential, specializing for tissue residency.
  • Later stages show distinct progenitor pathways for adaptive T cells and B cells.

Conclusions:

  • Immune cell seeding in peripheral tissues requires a stratified developmental process.
  • This stratification ensures efficient immune function and tissue homeostasis from embryonic stages onward.