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Related Concept Videos

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
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Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Related Experiment Video

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Acupuncture in a Rat Model of Asthma
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Diffuse idiopathic skeletal hyperostosis masquerading as asthma: case report.

Karim Mithani1, Ying Meng1, David Pinilla1

  • 1Divisions of1Neurosurgery and.

Journal of Neurosurgery. Spine
|April 27, 2019
PubMed
Summary
This summary is machine-generated.

A rare case shows diffuse idiopathic skeletal hyperostosis (DISH) mimicking asthma. Surgical removal of a cervical osteophyte resolved the patient's respiratory symptoms, highlighting a novel presentation of DISH.

Keywords:
anterior discectomy and fusionasthmacervical spinecompressiondiffuse idiopathic skeletal hyperostosis

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Area of Science:

  • Medicine
  • Pulmonology
  • Rheumatology

Background:

  • Asthma is a chronic respiratory condition often treated with corticosteroids.
  • Prolonged corticosteroid use can lead to serious side effects, such as avascular necrosis.
  • Diffuse idiopathic skeletal hyperostosis (DISH) is a systemic condition characterized by spinal ossification.

Observation:

  • A 52-year-old man with refractory asthma presented with recurrent exacerbations.
  • Physical examination and imaging revealed diffuse idiopathic skeletal hyperostosis (DISH) with a C7-T1 osteophyte compressing the trachea.

Findings:

  • Surgical decompression by anterior discectomy and fusion at C6-T1 resolved the patient's asthma symptoms.
  • Postoperative pulmonary function tests confirmed normalized FEV1/FVC ratio and no airway reactivity.

Implications:

  • This case suggests DISH can present as apparent asthma due to airway compression.
  • Highlights the importance of considering non-respiratory causes for refractory asthma-like symptoms.