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Published on: July 18, 2014
Mechanical Support for Patients With Congenitally Corrected Transposition of the Great Arteries and End-Stage
Kyle W Riggs1, Satsuki Fukushima2, Tomoyuki Fujita2
1Department of Cardiothoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Insights
Congenitally corrected transposition of the great arteries (ccTGA) patients often develop heart failure. Ventricular assist device (VAD) therapy shows promising results for these adults with congenital heart disease (ACHD).
Area of Science:
- Cardiology
- Adult Congenital Heart Disease (ACHD)
- Mechanical Circulatory Support
Background:
- Congenitally corrected transposition of the great arteries (ccTGA) leads to heart failure in adulthood despite medical advances.
- Adults with congenital heart disease (ACHD) are a small but significant group receiving ventricular assist devices (VADs).
- ccTGA represents a substantial portion (36%) of ACHD patients in the INTERMACS database requiring VADs.
Abstract:
Despite great advances in caring for patients with congenitally corrected transposition of the great arteries (ccTGA), a high proportion of these patients go on to develop heart failure and death in early adulthood. Adults with congenital heart disease (ACHD) only comprise a small number of patients receiving ventricular assist devices (VAD), but ccTGA accounted for 36% of ACHD patients in the INTERMACS database. Review of the literature describing ccTGA patients receiving VAD therapy shows promising results. With newer devices and the assistance of advanced imaging, mechanical circulatory support is becoming a desirable option for this population of patients and has the potential to provide significant long-term support, relieving them of heart failure symptoms and delaying and perhaps in the future avoiding, the need for cardiac transplantation.
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