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Published on: October 24, 2015
Expression of HDAC4 in Stage B Hepatocellular Carcinoma and Its Influence on Survival
Zhonghong Wang1, Honggang Wang2, Peng Shen2
1Department of Gastroenterology, Hongze District People's Hospital, Nanjing Medical University, Huai'an, China.
Objectives:
Histone deacetylase 4 (HDAC4) is involved in the development of multiple types of cancers. In this study, we aimed to investigate the expression and clinical significance of HDAC4 in hepatocellular carcinoma (HCC).
Methods:
49 patients with stage B HCC who underwent surgical resection were enrolled in this study. All patients were followed up with an observation time of 4.8 to 7 years. Immunohistochemistry was applied to investigate the expression level of HDAC4.
Results:
HDAC4 protein is over-expressed in HCC tissues compared with matched adjacent non-cancer tissues. Kaplan-Meier analysis shows that the positive expression of HDAC4 is associated with poor survival in these patients.
Conclusions:
Our study shows that HDAC4 over-expression is important for the development of advanced HCC, which may serve as a useful prognostic biomarker and therapeutic target for this malignancy.
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