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Updated: Jan 25, 2026

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
Molecular Evolution Bioinformatics Toward Structural Biology of TRPV1-4 Channels
Pau Doñate-Macián1, Alba Crespi-Boixader2, Alex Perálvarez-Marín3
1Unitat de Biofísica, Departament de Bioquímica i de Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain.
Abstract:
Bioinformatics is a very resourceful tool to understand evolution of membrane proteins, such as transient receptor potential channels. Expert bioinformatics users rely on specialized scripting and programming skills. Several web servers and standalone tools are available for nonadvanced users willing to develop projects to understand their system of choice. In this case, we present a desktop-based protocol to develop evostructural hypotheses based on basic bioinformatics skills and resources, specifically for a small subgroup of TRPV channels, which can be further implemented for larger datasets.
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