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Tailored chromatin modulation to promote tissue regeneration
Paloma Martinez-Redondo1, Juan Carlos Izpisua Belmonte1
1Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, United States.
Seminars in Cell & Developmental Biology
|April 28, 2019
Summary
Epigenetic mechanisms control cell identity and plasticity during tissue repair and regeneration. New CRISPR technologies offer tools to study and enhance these regenerative processes.
Area of Science:
- Molecular Biology
- Developmental Biology
- Regenerative Medicine
Background:
- Epigenetic regulation governs gene expression, maintaining cellular identity and plasticity.
- Epigenetic modulation is crucial for cellular de-differentiation, proliferation, and re-differentiation during tissue regeneration.
Purpose of the Study:
- To explore epigenetic events coordinating tissue repair in vertebrates and mammalian stem cells.
- To summarize CRISPR-based technologies for studying and promoting tissue regeneration.
Main Methods:
- Review of literature on epigenetic regulation in tissue repair.
- Analysis of epigenetic mechanisms in lower vertebrates and mammalian adult stem cells.
- Summary of recent advancements in CRISPR-based gene editing for regeneration.
Main Results:
- Epigenetic modifications are key to cellular plasticity during regeneration.
- Lower vertebrates and mammalian stem cells utilize distinct epigenetic strategies for repair.
- CRISPR technologies show potential for manipulating epigenetic events in regeneration.
Conclusions:
- Epigenetic regulation is fundamental for tissue repair and regeneration.
- Understanding these mechanisms can lead to novel regenerative therapies.
- CRISPR-based tools represent a promising avenue for advancing regenerative medicine.
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