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Updated: Jan 25, 2026

In Vitro Permeation of FITC-loaded Ferritins Across a Rat Blood-brain Barrier: a Model to Study the Delivery of Nanoformulated Molecules
Published on: August 22, 2016
Ferritin-based anticancer metallodrug delivery: Crystallographic, analytical and cytotoxicity studies
Dara Maria Monti1, Giarita Ferraro1, Antonello Merlino1
1Department of Chemical Sciences, University of Naples Federico II, Napoli, Italy.
Abstract:
The encapsulation of anticancer metal-based drugs within a protein nanocage represents a valuable strategy to improve the efficacy and selectivity of these compounds towards cancer cells. The preparation, characterization of the in vitro cytotoxicity and X-ray structures of several ferritin-metallodrug nanocomposites (mainly containing platinum-, ruthenium- and gold-based anticancer agents) are here reviewed. The molecular mechanisms of action of these Ft-metallodrug adducts are discussed and future directions in the field are outlined.
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