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Base Excision Repair

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
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Some compounds produce hydroxide ions when dissolved by chemically reacting with water molecules. In all cases, these compounds react only partially and so are classified as weak bases. These types of compounds are also abundant in nature and important commodities in various technologies. For example, global production of the weak base ammonia is typically well over 100 metric tons annually, being widely used as an agricultural fertilizer, a raw material for chemical synthesis of other...
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Related Experiment Video

Updated: Jan 25, 2026

Synthesis of Keratin-based Nanofiber for Biomedical Engineering
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Supramolecular-based nanofibers.

Yi Wang1, Joshua Chou2, Yulong Sun1

  • 1State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.

Materials Science & Engineering. C, Materials for Biological Applications
|April 29, 2019
PubMed
Summary
This summary is machine-generated.

Supramolecular nanofibers offer enhanced sensitivity and responsiveness for biomedical uses. This review highlights their development, focusing on electrospun and self-assembled types for controlled drug delivery.

Keywords:
ElectrospunInclusion complexNanofibersSelf-assemblySupramolecular interaction

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Nanotechnology

Background:

  • Supramolecular nanofibers combine supramolecular interactions with nanofibrous structures.
  • They offer advantages over traditional polymer nanofibers, including enhanced sensitivity and reversibility.
  • These nanofibers are suitable for various biomedical applications, notably controlled drug delivery.

Purpose of the Study:

  • To review recent advancements in supramolecular-based nanofibers.
  • To focus on electrospun supramolecular nanofibers and self-assembled nanofibers.
  • To discuss potential biomedical applications and future trends.

Main Methods:

  • Review of recent literature on supramolecular nanofibers.
  • Focus on electrospinning techniques for nanofiber fabrication.
  • Discussion of self-assembly methods for supramolecular nanofibers.

Main Results:

  • Supramolecular nanofibers exhibit rapid and reversible responses to external stimuli (e.g., pH, temperature).
  • Non-covalent binding modes overcome sensitivity limitations of traditional nanofibers.
  • Both electrospun and self-assembled supramolecular nanofibers show significant potential.

Conclusions:

  • Supramolecular nanofibers are a promising material for advanced biomedical applications.
  • Further research into their dynamic and controllable responsive functions is warranted.
  • Future trends point towards novel applications in drug delivery and regenerative medicine.