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Platelet to Lymphocyte Ratio in Cardiovascular Diseases: A Systematic Review

Alparslan Kurtul1, Ender Ornek2

  • 11 Cardiology Department, Tayfur Ata Sokmen Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Antakya, Turkey.

Angiology
|April 30, 2019
PubMed

Insights

The platelet-to-lymphocyte ratio (PLR) is a simple blood test marker. High PLR is linked to worse outcomes in cardiovascular diseases, suggesting its prognostic value.

Area of Science:

  • Cardiology
  • Hematology
  • Systemic Inflammation

Background:

  • The platelet-to-lymphocyte ratio (PLR) integrates thrombotic and inflammatory pathways.
  • Initially used for cancer prognosis, PLR is now explored as a cardiovascular biomarker.

Purpose of the Study:

  • To review evidence on the association between PLR and cardiovascular disease (CVD).
  • To evaluate PLR's potential as a prognostic marker for CVD outcomes.

Main Methods:

  • Systematic review of clinical trials indexed in PubMed, EMBASE, and Web of Science.
  • Data up to April 18, 2018, was assessed for PLR's association with mortality and major adverse cardiac events.

Main Results:

  • Most studies reviewed reported significant associations between elevated PLR and adverse outcomes in various cardiovascular conditions.
  • A high PLR was consistently linked to poorer prognoses in patients with CVD.

Conclusions:

  • The platelet-to-lymphocyte ratio (PLR) is an accessible and cost-effective marker of systemic inflammation.
  • PLR demonstrates potential as a valuable prognostic tool for predicting outcomes across different types of cardiovascular disease.

Keywords:
cardiovascular eventsinflammationplatelet to lymphocyte ratiothrombosis

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