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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells
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Engineering Tissues from Induced Pluripotent Stem Cells.

Peter Loskill1,2, Nathaniel Huebsch2

  • 11 Research Institute for Women's Health, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.

Tissue Engineering. Part A
|April 30, 2019
PubMed
Summary
This summary is machine-generated.

Human pluripotent stem cells, guided by cell and tissue engineering, offer new ways to model diseases and regenerate damaged tissues. Research highlights their potential and current challenges in regenerative medicine.

Keywords:
adult stem cellsembryonic stem cellsengineered tissueshuman induced pluripotent stem cells (hiPSC)induced pluripotent stem (iPS) cellsmicrophysiological systems (MPS)organ-on-a-chip

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Area of Science:

  • Regenerative Medicine
  • Developmental Biology
  • Tissue Engineering

Background:

  • Human pluripotent stem cells (hESC and hiPSC) enable the generation of specific cell types in vitro.
  • Cell and tissue engineering are crucial for utilizing stem cells in research and therapy.
  • These fields are advancing disease modeling and regenerative medicine.

Discussion:

  • Harnessing stem cells with engineering principles allows detailed study of disease and injury mechanisms.
  • This interdisciplinary approach facilitates the development of novel therapeutic strategies.
  • Current research showcases significant progress and identifies areas for future development.

Key Insights:

  • Engineered stem cell systems provide powerful tools for understanding complex biological processes.
  • The controlled generation of specific cell types is key to their therapeutic application.
  • Translating these advancements into clinical practice remains an active area of investigation.

Outlook:

  • Continued integration of cell and tissue engineering will accelerate stem cell applications.
  • Overcoming current challenges is vital for realizing the full potential of stem cell therapies.
  • Future research will focus on refining techniques for safer and more effective tissue regeneration.