Related Experiment Video
Updated: Jan 25, 2026
06:04
Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
Published on: July 4, 2018
9.2K
Correlation of Objective Pupillometry to Midline Shift in Acute Stroke Patients
Mohamed Osman1, Sonja E Stutzman1, Folefac Atem1
1Division of Neurocritical Care, Department of Neurology & Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas.
Summary
Horizontal brain shifts in stroke patients correlate with pupillary changes. Objective pupillometer data, including Neurological Pupil index (NPi) and constriction velocity (CV), show significant links to midline shift, aiding neurological assessment.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Pupillary dysfunction signals neurological deterioration in hemispheric stroke patients.
- Horizontal brain structure displacement may be key to pupillary changes.
- Pupillometers offer objective evaluation of the pupillary light reflex.
Purpose of the Study:
- To investigate the correlation between horizontal intracranial midline shift and pupillary data (NPi and CV) in stroke patients.
- To determine if objective pupillometer measurements can predict midline shift in acute stroke.
Main Methods:
- Utilized the ENDPANIC registry of 134 patients with ischemic or hemorrhagic stroke.
- Correlated horizontal shift of the septum pellucidum (SPS) with pupillary size, NPi, and CV from assessments within 6 hours of imaging.
- Employed regression analysis to control for confounding factors like age, race, and gender.
Main Results:
- Significant correlations found between SPS and NPi (left/right), CV (left/right), and pupillary asymmetry.
- No significant correlation was observed between SPS and pupillary size.
- Right pupil NPi and CV correlated with right-to-left SPS, but left pupil data did not correlate with left-to-right SPS.
Conclusions:
- Horizontal intracranial midline shift significantly correlates with NPi, CV, and pupillary asymmetry in stroke patients.
- Pupillary size does not correlate with horizontal midline shift.
- Objective pupillometer data provides valuable insights into brain shift in stroke.
Related Concept Videos
02:20Correlations
35.8K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.8K
01:27Correlation and Causation
42.4K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.4K
01:09Correlation
14.8K
In statistics, two variables are said to be correlated if the values of one variable are associated with the other variable. Depending on the relationship between two variables, correlation can be of three types– positive correlation, negative correlation, and zero correlation.
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
14.8K
01:29Potential Due to a Polarized Object
759
A neutral atom consists of a positively charged nucleus surrounded by a negatively charged electron cloud. When placed in an external electric field, the external electric force pulls the electrons and nucleus apart, opposite to the intrinsic attraction between the nucleus and the electrons. The opposing forces balance each other with a slight shift between the center of masses of the nucleus and the electron cloud, resulting in a polarized atom. On the other hand, a few molecules, like water,...
759
01:24Potential Due to a Magnetized Object
780
Magnetic dipoles in magnetic materials are aligned when placed under an external magnetic field. For paramagnets and ferromagnets, dipole alignment occurs in the direction of the magnetic field. However, the dipoles align opposite to the field in the case of diamagnets. This state of magnetic polarization due to the external field is called magnetization. Magnetization is defined as the dipole moment per unit volume. It plays a similar role to polarization in electrostatics.
The vector...
The vector...
780
00:53Correlation and Regression
3.2K
In statistics, correlation describes the degree of association between two variables. In the subfield of linear regression, correlation is mathematically expressed by the correlation coefficient, which describes the strength and direction of the relationship between two variables. The coefficient is symbolically represented by 'r' and ranges from -1 to +1. A positive value indicates a positive correlation where the two variables move in the same direction. A negative value suggests a...
3.2K