Related Experiment Video

Updated: Jan 25, 2026

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique
09:37

Detection of Polyfunctional T Cells in Children Vaccinated with Japanese Encephalitis Vaccine via the Flow Cytometry Technique

Published on: September 23, 2022

2.2K

Seroconversion following hepatitis B vaccination in children with chronic kidney disease

Nivedita Kamath1, Anil Vasudevan1, Arpana Iyengar1

  • 1Department of Pediatric Nephrology, St. John's Medical College Hospital, Bengaluru, Karnataka, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|April 30, 2019
PubMed

Insights

Hepatitis B vaccination shows low seroconversion rates in children with chronic kidney disease (CKD). Protective immunity also wanes quickly, necessitating antibody monitoring.

Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Vaccinology

Background:

  • Children with chronic kidney disease (CKD) exhibit reduced immune responses.
  • Hepatitis B vaccination is crucial for preventing infection in this vulnerable population.

Purpose of the Study:

  • To evaluate hepatitis B vaccine seroconversion rates in pediatric CKD patients.
  • To assess the persistence of protective immunity one year post-vaccination.

Main Methods:

  • Prospective observational study in a tertiary pediatric nephrology center.
  • Hepatitis B vaccination (10 μg) administered at 0, 1, and 2 months.
  • Seroconversion and antibody titers (>10 mIU/mL) assessed at baseline and one year; re-vaccination for non-responders.

Main Results:

  • Seroconversion achieved in 72% of children after the initial vaccination course.
  • Only 60% achieved seroconversion after a second vaccination course.
  • Protective antibody titers persisted in only 60% of initially seroconverted children at one year.

Conclusions:

  • Three doses of hepatitis B vaccine yield suboptimal seroconversion in children with CKD.
  • Antibody titers decline rapidly, indicating waning immunity.
  • Periodic monitoring of antibody titers is essential for managing hepatitis B immunity in pediatric CKD patients.

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.7K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.4K

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
613
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
601
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
377
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
342
Vaccinations01:51

Vaccinations

Overview
51.3K
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
266