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Updated: Jan 25, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Novel and efficient synthesis of insulating gas- heptafluoroisobutyronitrile from hexafluoropropylene
Zhanyang Gao1, Min Wang1, Shiyao Wang1
1Engineering Research Centre of Organosilicon Compounds and Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, People's Republic of China.
Abstract:
A novel and efficient preparation route of insulating gas-heptafluoroisobutyronitrile was developed. The synthetic route involved halogen-exchange fluorination, decomposition of bis-(perfluoroisopropyl) ketone and dehydration reaction. Overall, the desired compound was produced without the use of extremely toxic and expensive substances. Structures of the as-obtained products were determined by 19F NMR, 13C NMR, IR and GC-MS. The effects of several variables on reaction yield including nature of potassium fluoride, the catalyst dosage, temperature, solvent and molar ratio of raw materials were all investigated. The results indicated that the total yield of heptafluoroisobutyronitrile could reach 42% from original materials under optimal conditions and the mechanism of the reaction was proposed.
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