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Non-Invasive Model of Neuropathogenic Escherichia coli Infection in the Neonatal Rat
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Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Meningitis and Cerebral Abscess in a Neonate: Therapeutic

Surasak Puvabanditsin1, Marianne Jacob2, Maaz Jalil2

  • 1Associate Professor of Pediatrics, Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, One Robert Wood Johnson Place, New Brunswick, New Jersey 08903, USA.

Case Reports in Infectious Diseases
|April 30, 2019
PubMed

Insights

A neonate developed meningitis and brain abscess from ESBL-producing Escherichia coli. Vigilant antimicrobial use is crucial as these resistant infections rise.

Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Extended-spectrum beta-lactamase (ESBL) producing Escherichia coli infections are an increasing global health concern.
  • Neonates are particularly vulnerable to severe bacterial infections due to immature immune systems.

Observation:

  • A case of a 12-day-old neonate with meningitis and cerebral abscess caused by ESBL-producing E. coli is presented.
  • The neonate had a recent history of a 7-day antibiotic course prior to the current infection.

Findings:

  • The study highlights a severe invasive infection in a neonate attributed to a multidrug-resistant organism.
  • The presence of ESBL-producing E. coli indicates a significant challenge in treating neonatal sepsis and meningitis.

Implications:

  • This case underscores the critical need for judicious antimicrobial stewardship to combat the rise of highly resistant bacteria.
  • Effective infection prevention and control strategies are essential in neonatal intensive care units to mitigate the spread of ESBL-producing pathogens.

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