[Effects of aminooxyacetic acid on the learning and memory ability and its possible mechanism in rats with chronic alcoholism]
Related Experiment Video
Updated: Jan 25, 2026

Analysis of Learning and Memory Ability in an Alzheimer's Disease Mouse Model using the Morris Water Maze
Published on: October 29, 2019
Hao-Zhi Qin1, Hong-Bo Jiang1,2, Xuan Dai1
1Department of Physiology and Neurobiology and Sino-UK Joint Laboratory for Brain Function and Injury, Henan Provincial Key Laboratory of Brain Research, Xinxiang Medical University, Xinxiang 453003.
Objective:
To investigate the effects of aminooxyacetic acid (AOAA) on learning and memory ability and possible mechanisms in rats with chronic alcoholism.
Methods:
Sixty SD male rats were randomly divided into three groups on average.The model group rats and the remedy group rats were fed with the water containing (v/v) 6% alcohol for 28 days.After 14 days, the remedy group rats were treated with AOAA (5 mg/kg·d) by intraperitoneal injection once a day for 14 days and the other two group rats were treated with the equal amount of saline by intraperitoneal injection every day.Five days before the end of the experiment, the water maze test was carried out to test the learning and memory ability of rats for 5 days.Subsequently, the content of H2S, the activity of ATP enzyme and the expression of 5-HT in hippocampus were measured.
Results:
Compared with the rats in the control group, the latency and the swimming distance of the 2nd to the 4th day, the content of H2S in hippocampus of rats in the model group were all increased, the mitochondrial ATP enzyme activity in hippocampus and the positive expression of 5-HT in hippocampus CA1 and CA3 of rats in the model group were decreased (P<0.01).Compared with the rats in the model group, the latency and the swimming distance of the 2nd to the 4th day, the content of H2S in hippocampus of the rats in the remedy group were decreased, the mitochondrial ATP enzyme activity in hippocampus and the positive expression of 5-HT in hippocampus CA1 and CA3 of rats in the model group were increased (P<0.01).
Conclusions:
AOAA could alleviate the symptoms of chronic alcoholism rats, which may be related to the effects of AOAA on the content of H2S, the mitochondrial enzyme activity and the expression of 5-HT in hippocampus.
More Related Videos
Related Concept Videos
Acidity and Basicity of Alcohols and Phenols
Higher Mental Functions of Brain: Learning and Memory
Acid Halides to Alcohols: Grignard Reaction
Grignard reagents are a source of carbanions and function as nucleophiles. The mechanism begins with the nucleophilic attack by the carbanion at the carbonyl carbon of the acid halide to form a tetrahedral intermediate. Next, the carbonyl group is re-formed, and the halide ion departs,...
Acid-Catalyzed Dehydration of Alcohols to Alkenes
Substituent Effects on Acidity of Carboxylic Acids
Carboxylic Acids to Primary Alcohols: Hydride Reduction

