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CANCROX: a cross-species cancer therapy database
Paulo Muniz de Ávila1,2, Diego Cesar Valente E Silva1,3, Paulo Cesar de Melo Bernardo1,3
1Biotechnology Unit, University of Ribeirão Preto, Av. Costábile Romano, Ribeirão Preto, SP, Brazil.
Database : the Journal of Biological Databases and Curation
|April 30, 2019
Summary
A new database, CANCROX, links human and canine cancer genes and therapies. This computational model aids comparative oncology research by organizing drug and gene information for 40 cancer types.
Area of Science:
- Comparative Oncology
- Bioinformatics
- Computational Biology
Background:
- Cancer is a complex group of over 200 diseases characterized by uncontrolled cell growth and metastasis.
- The presence of similar cancer types in humans and animals, particularly dogs, fuels interest in comparative oncology.
- Existing research lacks a centralized, integrated resource for human and canine cancer-related genetic and therapeutic information.
Purpose of the Study:
- To develop a computational model for constructing a reference database of human and canine genes associated with cancer.
- To integrate information on cancer types, genetic pathways, drugs, and therapies for both humans and dogs.
- To create a user-friendly interface and data visualization tools for exploring cancer research data.
Main Methods:
- Utilized bioinformatics tools, text mining, and natural language processing to build the CANCROX database.
- Processed extensive scientific literature to identify and link human and canine cancer-related genes and genetic pathways.
- Compiled a comprehensive list of over 1300 drugs, therapies, and more than 10,000 drug combinations for 40 cancer types.
Main Results:
- The CANCROX reference database was successfully constructed, containing information on human and canine cancer genes and therapies.
- The database includes over 1300 drugs, 10,000+ drug combinations, and data for 40 types of cancer.
- A user-friendly interface with data visualization tools was developed for efficient data exploration and analysis.
Conclusions:
- The CANCROX database provides a valuable, integrated resource for comparative oncology research.
- This tool facilitates the exploration of genetic pathways, drug therapies, and drug combinations for human and canine cancers.
- The developed interface supports researchers in advancing cancer studies in both human and animal models.
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