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Intraperitoneal vancomycin in neonates during peritoneal dialysis: A case report.
María José Company-Albir1, Ana García-Robles2, Ester Torres-Martinez2,3
1Pharmacy Department, Health Research Institute La Fe (IIS La Fe), Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Journal of Clinical Pharmacy and Therapeutics
|April 30, 2019
Summary
Vancomycin dosing for neonatal peritonitis during peritoneal dialysis varies widely. Further research is needed to establish optimal vancomycin dosage and serum levels in newborns undergoing peritoneal dialysis.
Area of Science:
- Nephrology
- Neonatology
- Pharmacology
Background:
- Current guidelines recommend vancomycin for peritonitis in pediatric patients.
- Limited data exists on vancomycin use in neonates undergoing peritoneal dialysis.
Observation:
- A case report details a neonate with acute renal failure on continuous peritoneal dialysis.
- Intraperitoneal vancomycin was administered, with dosage and serum levels documented.
Findings:
- Significant variability exists in recommended vancomycin doses for continuous peritoneal dialysis.
- Clinical experience with vancomycin in this population is limited.
Implications:
- Further investigation into optimal vancomycin dosing, particularly loading doses, is crucial for neonates.
- Evidence-based dosing strategies are needed to ensure effective treatment and minimize toxicity.
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