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Related Concept Videos

Quality Assurance01:19

Quality Assurance

1.1K
Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
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DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Quality of Water01:19

Quality of Water

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In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
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Quality Control01:05

Quality Control

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Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
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Pulse amplitude and quality01:17

Pulse amplitude and quality

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Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
A weak or absent pulse may indicate reduced cardiac output or poor left ventricular contraction, which can be signs of cardiovascular dysfunction or...
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Testing Water Quality01:14

Testing Water Quality

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When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
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Related Experiment Video

Updated: Jan 25, 2026

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
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Recommendations for Tissue Microarray Construction and Quality Assurance.

Betty Glinsmann-Gibson1, Lee Wisner1, Melissa Stanton2

  • 1Departments of Research.

Applied Immunohistochemistry & Molecular Morphology : AIMM
|April 30, 2019
PubMed
Summary
This summary is machine-generated.

Standardized quality assurance for tissue microarrays (TMAs) is crucial for reliable research. This study presents methods for constructing TMAs and quality control measures to ensure dependable experimental results from biobanks.

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DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning
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Area of Science:

  • Biopathology
  • Biotechnology
  • Cancer Research

Background:

  • Tissue microarrays (TMAs) are vital for conserving tissue resources and reducing experimental variability.
  • Standardized quality assurance (QA) for TMAs from biobanks is currently lacking.
  • Centralized biobanking requires robust methods for TMA construction and QA.

Purpose of the Study:

  • To outline standardized processes for tissue microarray (TMA) construction.
  • To detail preconstruction quality control measures for TMA materials.
  • To provide a framework for biobanks to ensure TMA quality for end-users.

Main Methods:

  • Described two TMA construction methods: the "recipient block" and "tape" techniques.
  • Detailed preconstruction QA measures including pathology review, protein and RNA assessment, map creation, and storage condition monitoring.
  • Developed these processes within the AIDS Cancer Specimen Resource (ACSR) Network's Science and Technology Core.

Main Results:

  • Presented standardized protocols for TMA construction and quality control.
  • Established a framework for assessing TMA material quality before distribution.
  • Aimed to enhance confidence in experimental results derived from biobanked TMA samples.

Conclusions:

  • The proposed framework offers a standardized approach to TMA quality assurance.
  • Implementation of these methods can improve the reliability of research using TMA resources.
  • Standardized QA for TMAs is essential for advancing cancer research and diagnostics.