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Related Experiment Video

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Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
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Aging circadian rhythms and cannabinoids.

Erik L Hodges1, Nicole M Ashpole1

  • 1Pharmacology Division, Department of BioMolecular Sciences, University of Mississippi School of Pharmacy, Oxford, MS, USA.

Neurobiology of Aging
|April 30, 2019
PubMed
Summary
This summary is machine-generated.

Circadian rhythms decline with age, but cannabinoids may offer benefits. Low doses of cannabinoids might reverse age-related impairments by influencing circadian clocks, suggesting therapeutic potential for aging physiology.

Keywords:
Advanced ageCannabisChronobioticChronopharmacologyCircadian rhythmCognitionEndocannabinoidHormesis

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Area of Science:

  • Neurobiology
  • Chronobiology
  • Pharmacology

Background:

  • Mammalian physiology features daily circadian rhythms, which degrade with age.
  • Disrupted circadian rhythms and age-related impairments may share a common mechanism.
  • The endocannabinoid system influences circadian physiology and aging.

Purpose of the Study:

  • To assess the therapeutic potential of modulating the endocannabinoid system in aged individuals.
  • To explore the dose-dependent effects of cannabinoids on circadian rhythms and aging processes.
  • To investigate the role of hormesis in cannabinoid's effects on aging.

Main Methods:

  • Review of existing literature on biological aging, circadian rhythms, and endocannabinoid signaling.
  • Analysis of studies on cannabinoid receptor-1 (CB1) agonists.
  • Examination of evidence for hormetic effects of cannabinoids.

Main Results:

  • CB1 agonists typically reduce neuronal activity, body temperature, locomotion, and cognition.
  • Paradoxical evidence suggests low-dose cannabinoids may benefit aged subjects.
  • Hormesis, a biphasic dose-response, may explain these beneficial low-dose effects.

Conclusions:

  • Precise administration of exogenous cannabinoids could potentially entrain circadian clocks.
  • Cannabinoid modulation may offer therapeutic benefits for multiple aspects of aging physiology.
  • Further research is needed to confirm hormetic properties and optimize cannabinoid therapy for aging.