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Related Experiment Video

Updated: Jan 25, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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[Diagnosing von Willebrand disease].

Fie Juhl Vojdeman1, Malou Philips, Eva Funding

  • 1fie.juhl.vojdeman@regionh.dk.

Ugeskrift for Laeger
|May 1, 2019
PubMed
Summary

Von Willebrand disease (VWD) is an underdiagnosed inherited bleeding disorder affecting approximately 50,000 people in Denmark. Improved screening in high-risk groups could help diagnose more patients and enable prophylactic treatment.

Area of Science:

  • Hematology
  • Genetics
  • Public Health

Background:

  • Von Willebrand disease (VWD) is an inherited bleeding disorder characterized by abnormal primary hemostasis.
  • It results from defects in or reduced levels of the von Willebrand factor glycoprotein.
  • The estimated prevalence in Denmark is 1%, affecting around 50,000 individuals.

Purpose of the Study:

  • To highlight the significant underdiagnosis of VWD in Denmark.
  • To emphasize the need for improved screening methods for bleeding disorders.
  • To advocate for early diagnosis and prophylactic treatment in high-risk populations.

Main Methods:

  • The study focuses on the prevalence and diagnostic challenges of VWD in Denmark.
  • It reviews the clinical presentation and diagnostic criteria for VWD.

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  • It discusses the implications of underdiagnosis on patient management.

    • Main Results:

    • VWD is significantly underdiagnosed, with only a few hundred cases formally diagnosed in Denmark.
    • Diagnosis is often delayed until after trauma or surgery due to prolonged bleeding.
    • The majority of affected individuals remain undiagnosed in the general population.

    Conclusions:

    • VWD is a prevalent yet underdiagnosed condition in Denmark.
    • Enhanced anamnestic screening for bleeding disorders in high-risk groups is crucial.
    • Prophylactic treatment facilitated by early diagnosis can improve patient outcomes.