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Updated: Jan 25, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
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Ototoxicity: Visualized in Concept Maps.

Kelly L Watts1,2

  • 1US Department of Defense Hearing Center of Excellence, San Antonio, Texas.

Seminars in Hearing
|May 1, 2019
PubMed
Summary
This summary is machine-generated.

Ototoxicity, damage to the auditory system from drugs or chemicals, affects hearing and balance. Emerging research focuses on otoprotectants and otorescue agents for prevention and treatment.

Keywords:
concept mapototoxicityototoxicity monitoringototoxins

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Area of Science:

  • Oto-neuroscience
  • Toxicology
  • Pharmacology

Background:

  • Ototoxicity is damage to the auditory-vestibular system from external agents like medications, chemicals, and radiation.
  • Hundreds of medications can cause hearing and/or balance impairment, highlighting a significant public health concern.
  • Ototoxicity includes damage to the cochlea, vestibular system, and associated nerves.

Purpose of the Study:

  • To define and visually represent the complex knowledge domains and relationships within ototoxicity.
  • To provide a framework for understanding the causation, prevention, and management of ototoxic effects.
  • To highlight the need for otoprotective and otorescue agent development.

Main Methods:

  • Conceptual mapping of ototoxicity knowledge pathways.
  • Review of existing literature on ototoxic agents and effects.
  • Synthesis of information from various professional disciplines involved in ototoxicity.

Main Results:

  • Presentation of original concept maps illustrating ototoxicity relationships.
  • Identification of key areas within ototoxicity research and clinical practice.
  • Demonstration of the interdisciplinary nature of ototoxicity management.

Conclusions:

  • Understanding ototoxicity requires integrating knowledge from diverse fields.
  • Developing otoprotectants and otorescue agents is a critical emerging area.
  • Concept maps serve as valuable tools for organizing and disseminating ototoxicity knowledge.