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Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
Published on: March 1, 2020
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A diffuse large B cell lymphoma emerging with breast cancer relapse
Abdulkadir Karismaz1, Mehmet Hilmi Dogu1, Gülben Huq2
1University of Health Sciences, Istanbul Training and Research Hospital, Department of Hematology, Istanbul, Turkey.
The Pan African Medical Journal
|May 1, 2019
Summary
Secondary high-grade B-cell lymphoma developed in a breast cancer patient 4 years after diagnosis. This rare case highlights the importance of careful chemotherapy dosing to prevent long-term side effects.
Area of Science:
- Oncology
- Hematology
Background:
- Secondary malignancies are an increasing concern in breast cancer survivors.
- Treatment modalities like chemotherapy and radiotherapy can contribute to secondary cancer development.
Observation:
- A 54-year-old female with a 4-year history of breast cancer presented with fatigue and epistaxis.
- Initial investigations revealed pancytopenia, with bone marrow biopsy showing CD20-positive high-grade B-cell lymphoma.
Findings:
- The patient received chemotherapy, showing initial hemogram improvement.
- However, interim PET-CT indicated an incomplete response, and a subsequent biopsy confirmed breast cancer metastasis, not secondary lymphoma.
- This represents an unusual presentation of secondary diffuse large B-cell lymphoma (DLBCL) with pancytopenia, occurring four years post-breast cancer diagnosis.
Implications:
- This case underscores the critical need for precise chemotherapy dosage to mitigate long-term adverse effects.
- Clinicians must maintain vigilance for secondary malignancies in breast cancer patients undergoing long-term treatment.
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