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Related Experiment Video

Updated: Jan 25, 2026

Rapid Isolation of Single Cells from Mouse and Human Teeth
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Periostin and Human Teeth.

Teresa Cobo1,2, Juan L Cobo3,4, Juan C Pérez-Varela5

  • 1Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Universidad de Oviedo, Oviedo, Spain.

Advances in Experimental Medicine and Biology
|May 1, 2019
PubMed
Summary
This summary is machine-generated.

Periostin, a protein crucial for connective tissues, is present in human teeth, specifically the periodontal ligament, gingiva, and dental pulp. This study details its distribution in these vital oral structures.

Keywords:
Dental pulpGingivaHumanOrthodontic movementsPeriodontal ligamentPeriostinSubodontoblastic layer

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Area of Science:

  • Oral Biology
  • Connective Tissue Research
  • Biochemistry

Background:

  • Periostin is a secreted matricellular protein interacting with extracellular matrix components like collagen I and fibronectin.
  • It is abundant in collagen-rich connective tissues, with expression regulated by mechanical load.
  • While known in murine models, periostin's presence in human dental tissues is not well-documented.

Purpose of the Study:

  • To update and summarize the available data on periostin distribution in human dental tissues.
  • To investigate the presence of periostin in the human periodontal ligament, gingiva, and dental pulp.

Main Methods:

  • Literature review and data synthesis.
  • Analysis of existing studies on periostin expression in human oral tissues.

Main Results:

  • Periostin is confirmed to be distributed within the human periodontal ligament.
  • Evidence indicates periostin is also present in the human gingiva.
  • The study summarizes data on periostin's presence in the human dental pulp.

Conclusions:

  • Periostin is demonstrably present in key human dental tissues: periodontal ligament, gingiva, and dental pulp.
  • This confirms its role in the extracellular matrix of human oral connective tissues.
  • Further research can explore periostin's specific functions in human dental health and disease.