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Periostin in Eye Diseases.

Shigeo Yoshida1, Yumi Umeno2, Masatoshi Haruta2

  • 1Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan. yoshi@med.kurume-u.ac.jp.

Advances in Experimental Medicine and Biology
|May 1, 2019
PubMed
Summary

Periostin is implicated in various eye diseases by promoting fibrovascular tissue formation. Targeting periostin offers a potential new therapy for conditions like diabetic retinopathy and glaucoma.

Keywords:
Age-related macular degenerationAtopic keratoconjunctivitisChoroidConjunctivaCorneaCorneal dystrophyEpiretinal membranesFibrosisFibrovascular membranesGenome-wide gene expression profilingGlaucomaIL-13IL-4Mouse model of laser-induced choroidal neovascularizationMouse model of oxygen-induced retinal neovascularizationNeovascularizationProliferative diabetic retinopathyProliferative vitreoretinopathyPterygiaRetinaSerumSingle-stranded RNA interferenceTearVitreoretinal disease

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Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Pathology

Background:

  • Eye transparency is crucial for vision and can be compromised by various diseases.
  • Periostin is increasingly recognized for its role in the development of several ocular pathologies.

Purpose of the Study:

  • To investigate the role of periostin in the pathogenesis of eye diseases characterized by fibrovascular tissue formation.
  • To explore periostin as a potential therapeutic target for these conditions.

Main Methods:

  • Gene expression profiling of human retinal fibrovascular membranes.
  • Analysis of periostin expression following environmental perturbations like IL-4 and IL-13 induction.

Main Results:

  • Significant up-regulation of periostin was observed in human retinal fibrovascular membranes.
  • Periostin expression is influenced by inflammatory signals, altering cellular interactions within the eye.

Conclusions:

  • Periostin is a key factor in the pathogenesis of multiple eye diseases, including diabetic retinopathy, age-related macular degeneration, and glaucoma.
  • Modulating periostin expression presents a promising therapeutic strategy for treating these debilitating ocular conditions.