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Updated: Jan 25, 2026

Vessel-sparing Excision and Primary Anastomosis
Published on: January 7, 2019
Primary Anastomosis for Perforated Diverticulitis with Peritonitis: Post-hoc Pooled Analysis of Prospective
Mahir Gachabayov1, Christian E Oberkofler2, Gian Andrea Binda3
1Department of Surgery, Westchester Medical Center, New York Medical College, Valhalla, NY.
Insights
This study analyzed interventions for perforated diverticulitis with peritonitis undergoing resection with primary anastomosis (PRA). It aimed to identify if specific interventions impact patient outcomes after PRA surgery.
Area of Science:
- Surgical Gastroenterology
- Colorectal Surgery
- Diverticular Disease Research
Background:
- Perforated diverticulitis with peritonitis presents complex surgical challenges.
- Resection with primary anastomosis (PRA) is a debated approach for this condition.
- The influence of specific intraoperative interventions on PRA outcomes remains unclear.
Purpose of the Study:
- To evaluate the effect of specific interventions during resection with primary anastomosis (PRA).
- To determine if these interventions influence outcomes in patients with perforated diverticulitis and peritonitis.
- To provide evidence-based insights for surgical decision-making in this patient group.
Main Methods:
- Pooled analysis of existing studies on perforated diverticulitis with peritonitis.
- Inclusion of patients who underwent resection with primary anastomosis (PRA).
- Comparison of outcomes based on specific intraoperative interventions performed during PRA.
Main Results:
- Analysis of outcomes such as anastomotic leak, intra-abdominal abscess, and reoperation rates.
- Identification of specific interventions associated with improved or worsened patient outcomes.
- Statistical evaluation of the impact of each intervention on PRA success.
Conclusions:
- Specific interventions during resection with primary anastomosis (PRA) may significantly influence outcomes.
- Findings can guide surgeons in selecting optimal strategies for perforated diverticulitis with peritonitis.
- Further research may refine best practices for PRA in this setting.
Background:
The impact of specific interventions at resection with primary anastomosis (PRA) for perforated diverticulitis with peritonitis is controversial. The aim of this pooled analysis was to determine whether any specific interventions performed at resection with primary anastomosis in patients with perforated diverticulitis with peritonitis influenced the outcomes.
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