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Establishment of Gastric Cancer Patient-derived Xenograft Models and Primary Cell Lines
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WASF3 expression correlates with poor prognosis in gastric cancer patients
Yanli Nie1, Sheng Hu1, Sanhe Liu1
1Department of Gastrointestinal Medical Oncology, The Hubei Cancer Hospital, Huazhong University of Science & Technology, Wuhan 430079, PR China.
Abstract:
Aim: WASF3 has been shown to be required for invasion and metastasis in different cancers, this study is to explore the prognostic value of WASF3 in gastric cancer. Materials & methods: The coexpression of WASF3 and E-cadherin in gastric cancer patients and cells were evaluated. Results: WASF3 was overexpressed and the expression of E-cadherin was decreased in gastric cancer tissues compared with normal tissues (p < 0.001). WASF3 expression is associated with decreased expression of E-cadherin (p = 0.002). Patients with WASF3-positive expression had a poorer prognosis. The multivariate analysis showed that WASF3 expression is an independent prognostic factor related to overall survival (p = 0.027). Conclusion: Our analysis demonstrates that WASF3 expression correlates with poor outcomes and is a potential prognostic factor in gastric cancer patients.
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