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Eisosomes at the intersection of TORC1 and TORC2 regulation
1Henry Eyring Center for Cell and Genome Science, University of Utah, Salt Lake City, Utah.
Traffic (Copenhagen, Denmark)
|May 1, 2019
Summary
Eisosomes, yeast plasma membrane domains, regulate nutrient uptake and metabolic pathways by interacting with TORC1. They also manage membrane stress responses involving Slm1/2, TORC2, and lipid synthesis.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Eisosomes are specialized membrane domains in yeast.
- They play a role in nutrient transport and metabolic regulation.
- Eisosomes contain membrane stress sensors Slm1 and Slm2.
Purpose of the Study:
- To investigate the role of eisosomes in regulating proton-nutrient symporters.
- To understand how eisosomes influence TORC1 and TORC2 signaling pathways.
- To elucidate the mechanism of membrane stress sensing and response involving eisosomes.
Main Methods:
- Analysis of yeast plasma membrane composition.
- Studies on proton-nutrient symporter activity.
- Investigation of Slm1/2 localization and redistribution under hypoosmotic shock.
- Assessment of TORC1 and TORC2 pathway activation.
Main Results:
- Eisosomes regulate proton-nutrient symporter activity, impacting nutrient uptake.
- Nutrient import via symporters activates the metabolic regulator TORC1.
- Eisosomes harbor membrane stress sensors Slm1 and Slm2.
- Hypoosmotic shock induces Slm1/2 redistribution from eisosomes to TORC2, regulating lipid synthesis.
Conclusions:
- Eisosomes are crucial regulators of nutrient transport and metabolic signaling via TORC1.
- Eisosomes act upstream of both TORC1 and TORC2 pathways.
- Eisosomes are involved in sensing and responding to membrane tension, influencing lipid synthesis.
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