Related Experiment Video

Updated: Jan 25, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.8K

Management algorithms for metastatic prostate cancer

Shawn Malone1, Bobby Shayegan2, Naveen S Basappa3

  • 1The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada
|May 1, 2019
PubMed
Abstract

Insights

Canadian experts developed new treatment guidelines for metastatic prostate cancer (mPCa). These algorithms offer updated recommendations for managing both castration-sensitive (mCSPC) and castration-resistant (mCRPC) stages of the disease.

Area of Science:

  • Urology
  • Medical Oncology
  • Clinical Practice Guidelines

Background:

  • Prostate cancer (PCa) presents a significant lifetime risk for Canadian men.
  • Current clinical guidance for metastatic prostate cancer (mPCa) management is lacking up-to-date information.
  • The Canadian Genitourinary Research Consortium (GURC) identified the need for updated mPCa management guidance.

Purpose of the Study:

  • To develop updated clinical guidance for the management of metastatic prostate cancer (mPCa).
  • To create evidence-based treatment algorithms for mPCa based on recent guidelines and trials.
  • To provide recommendations for multidisciplinary teams managing mPCa.

Main Methods:

  • A comprehensive review of the latest guidelines, consensus statements, and phase 3 trials was conducted.
  • A multidisciplinary genitourinary oncology panel developed treatment algorithms for mPCa.
  • Algorithms were created for newly diagnosed metastatic castration-sensitive prostate cancer (mCSPC) and metastatic castration-resistant prostate cancer (mCRPC).

Main Results:

  • Two distinct treatment algorithms for mPCa management were developed.
  • For mCSPC with high-volume/high-risk disease, docetaxel or abiraterone acetate and prednisone (AAP) with androgen-deprivation therapy (ADT) is recommended.
  • For first-line mCRPC, androgen receptor-axis-targeted (ARAT) therapy is recommended, with various sequencing options for later lines.

Conclusions:

  • Two practical treatment algorithms for mPCa management have been established.
  • These algorithms can assist multidisciplinary specialist teams in guiding patient treatment.
  • The developed algorithms represent an updated approach to mPCa care in Canada.

More Related Videos

Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer08:54

Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer

Published on: June 13, 2019

11.4K
miRNA Expression Analyses in Prostate Cancer Clinical Tissues11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.2K

Related Concept Videos

Trial and Error and Algorithm01:12

Trial and Error and Algorithm

A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
403
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
303
Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
416
Impression Management Techniques I: Managing Appearances01:29

Impression Management Techniques I: Managing Appearances

Appearance is a multidimensional aspect of self-presentation that encompasses observable attributes such as clothing, grooming, speech, and nonverbal behavior. These elements are often strategically managed to align with socially constructed expectations in different settings. For instance, individuals tailor their appearance during job interviews, social gatherings, or athletic events to meet the perceived norms of those environments.Contextual Adaptation and Social SignalsThe research...
207
Management of Insomnia01:19

Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
564
Managing Impressions01:19

Managing Impressions

Impression management encompasses individuals' deliberate efforts to shape how others perceive them during social interactions. This behavior is often employed to conform to social norms, secure approval, or pursue specific goals. While it involves selective self-presentation, it is not necessarily deceptive; individuals frequently present authentic aspects of themselves that align with situational demands.Common strategies include:Ingratiation: where individuals use flattery or agreeableness...
168