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Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

H Piwnica-Worms, K B Saunders, T M Roberts

    Cell
    |April 10, 1987
    PubMed

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    When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze the...
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