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Updated: Jan 25, 2026

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
Published on: March 21, 2025
Reversed size-dependent stabilization of ordered nanophases
J Pirart1, A Front2, D Rapetti3
1Université d'Orléans, CNRS, ICMN UMR7374, 1b rue de la Férollerie, 45071, Orléans Cedex 2, France.
Abstract:
The size increase of a nanoscale material is commonly associated with the increased stability of its ordered phases. Here we give a counterexample to this trend by considering the formation of the defect-free L11 ordered phase in AgPt nanoparticles, and showing that it is better stabilized in small nanoparticles (up to 2.5 nm) than in larger ones, in which the ordered phase breaks in multiple domains or is interrupted by faults. The driving force for the L11 phase formation in small nanoparticles is the segregation of a monolayer silver shell (an Ag-skin) which prevents the element with higher surface energy (Pt) from occupying surface sites. With increasing particle size, the Ag-skin causes internal stress in the L11 domains which cannot thus exceed the critical size of ~2.5 nm. A multiscale modelling approach using full-DFT global optimization calculations and atomistic modelling is used to interpret the findings.
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