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Factors associated with chronic obstructive pulmonary disease exacerbation, based on big data analysis
Jongmin Lee1, Hyun Myung Jung2, Sook Kyung Kim2
1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Scientific Reports
|May 2, 2019
Summary
Identifying factors that trigger chronic obstructive pulmonary disease (COPD) exacerbations is key. This study found that a patient's history, sex, COPD grade, influenza virus, and low temperatures significantly predict exacerbations.
Area of Science:
- Pulmonary Medicine
- Environmental Health
- Epidemiology
Background:
- Preventing exacerbations in chronic obstructive pulmonary disease (COPD) is vital for patient outcomes.
- Identifying exacerbating factors requires integrated analysis of patient and environmental data.
- Previous studies have not comprehensively analyzed both patient-derived and external factors for COPD exacerbation.
Purpose of the Study:
- To identify patient-derived and external factors associated with COPD exacerbations.
- To analyze the combined impact of individual health status, environmental conditions, and public health trends on COPD exacerbations.
Main Methods:
- Collected data from 594 COPD patients (Korean COPD subgroup study - KOCOSS) including smoking status, lung function, and COPD assessment test scores.
- Merged patient data with Korean Health Insurance Review and Assessment Service data (2007-2012).
- Incorporated external data: weather variables (particulate matter, temperature), respiratory virus activity, and COPD-related web query logs.
Main Results:
- Univariate analysis indicated associations between exacerbations and patient factors, air pollution, viruses, temperature, and COPD-related web searches.
- Multivariate analysis identified significant predictors: prior exacerbation history, female sex, COPD grade, influenza virus detection rate, and lowest ambient temperature.
- These factors collectively contribute to predicting COPD exacerbation risk.
Conclusions:
- A patient's medical history, demographic factors, and environmental exposures like influenza and low temperatures are significant predictors of COPD exacerbations.
- Findings can aid in predicting exacerbation likelihood for timely patient interventions.
- Integrated analysis of diverse data sources offers a robust approach to understanding COPD exacerbation triggers.
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