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Cryptococcus gattii meningitis in a diabetic adult in South India

Mithilesh Kumar Jha1, Aroop Mohanty1, Pratima Gupta1

  • 1Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Journal of Family Medicine and Primary Care
|May 2, 2019
PubMed

Insights

Cryptococcosis can affect non-HIV patients, including those with diabetes. This case highlights fatal Cryptococcus gattii meningitis in a diabetic, HIV-negative individual.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Neuroscience

Background:

  • Cryptococcosis is an opportunistic infection primarily affecting immunocompromised individuals.
  • Cryptococcal meningitis is a common neuro-infection in HIV-positive patients.
  • It can also occur in non-HIV immunocompromised patients, including those with chronic glucocorticoid use, organ transplants, malignancy, sarcoidosis, and rarely, diabetes.

Observation:

  • A fatal case of Cryptococcus gattii meningitis occurred in a 56-year-old male patient.
  • The patient was HIV-negative and had diabetes mellitus.

Findings:

  • This case presents Cryptococcus gattii meningitis in an HIV-negative diabetic patient.
  • It underscores the potential for cryptococcosis in non-traditional immunocompromised populations.

Implications:

  • Highlights the importance of considering cryptococcosis in diabetic patients presenting with neurological symptoms.
  • Suggests a need for increased awareness and potentially revised diagnostic approaches for cryptococcosis in immunocompromised individuals beyond HIV.
  • Emphasizes the severe outcomes possible even in non-HIV associated cryptococcal meningitis.
Keywords:
CryptococcosisCryptococcus gattiidiabetes mellitusmeningitis

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