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Related Experiment Videos

Acid-base balance during biofiltration.

B Agazia, C Lombini, L Guarda

    The International Journal of Artificial Organs
    |December 1, 1986
    PubMed
    Summary

    Switching from acetate dialysis to biofiltration rapidly corrects acidosis. However, early biofiltration may cause alkalosis, which stabilizes after one year, reducing acid-base balance variations and alkalotic rebounds.

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    Area of Science:

    • Nephrology
    • Clinical Chemistry

    Background:

    • Acetate dialysis (AD) can lead to acid-base imbalance.
    • Biofiltration (BF) is an alternative dialysis method with potential benefits for acid-base balance.

    Purpose of the Study:

    • To evaluate the impact of switching from acetate dialysis to biofiltration on patients' pre-dialytic acid-base balance (ABB).
    • To assess the short-term and long-term effects of biofiltration on acid-base homeostasis.

    Main Methods:

    • Five patients on AD were switched to BF.
    • Acid-base balance was monitored during AD (period A) and at two months (period B) and 12 months (period C) after initiating BF.
    • Blood samples were analyzed for ABB at multiple time points during and after dialysis sessions.

    Main Results:

    • A rapid correction of AD-induced acidosis was observed within two months of starting BF.
    • Early BF (period B) showed a tendency towards alkalosis, with potential risks if superimposed with respiratory alkalosis.
    • After one year of BF (period C), there was a significant reduction in pCO2 fluctuations and pH variations, with no observed alkalotic rebounds.

    Conclusions:

    • Biofiltration effectively corrects acetate dialysis-induced acidosis.
    • While initial BF may lead to transient alkalosis, long-term use (12 months) stabilizes acid-base balance, reducing risks associated with alkalotic rebounds.

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