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Updated: Jan 25, 2026

Preparation of Exosomes for siRNA Delivery to Cancer Cells
Published on: December 5, 2018
Nischarin Regulates Secretion of Exosomes and Cancer Progression
Kathleen M McAndrews1, Raghu Kalluri1
1Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas. KMMcAndrews@mdanderson.org rkalluri@mdanderson.org.
Abstract:
The intercellular exchange of exosomes may play a regulatory function in tumor progression and metastasis. Maziveyi and colleagues demonstrated that Nischarin regulated the secretion of exosomes from breast cancer cells. Loss of Nischarin expression increased exosome production and promoted tumor cell growth and migration, supporting that Nischarin can influence the behavior of surrounding cancer cells. This study identified a novel function of the tumor suppressor Nischarin in exosome biology and cancer progression.See related article by Maziveyi et al., p. 2152.
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