Related Experiment Video
Updated: Jan 25, 2026
07:58
Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Published on: February 24, 2023
817
Pathway-based network analyses and candidate genes associated with Kashin-Beck disease
Rongqiang Zhang1,2, Hao Guo1, Xiaoli Yang1
1School of Public Health, Xi'an Jiaotong University Health Science Center, Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission of the People's Republic of China, Xi'an.
Medicine
|May 3, 2019
Summary
This study analyzed Kashin-Beck disease (KBD) genes using bioinformatics, identifying key biological functions and pathways involved in KBD pathogenesis. Findings suggest apoptosis and oxidative stress genes may aid in early KBD diagnosis and treatment.
Area of Science:
- Bioinformatics
- Genetics
- Molecular Biology
Background:
- Kashin-Beck disease (KBD) is a severe endemic skeletal disease.
- Understanding the genetic basis and molecular mechanisms of KBD is crucial for developing effective interventions.
Purpose of the Study:
- To conduct a comprehensive bioinformatics analysis of KBD-related genes.
- To elucidate the biological functions and interactions of these genes.
- To identify potential molecular targets for KBD pathogenesis.
Main Methods:
- Retrospective integrated bioinformatics analysis.
- Literature review to identify 922 KBD-associated genes.
- Network analysis using Cytoscape and MCODE algorithm.
Main Results:
- Enrichment analysis highlighted collagen catabolic process, apoptosis, and growth factor signaling in KBD development.
- Key pathways identified include apoptosis, NF-kappa B signaling, and glutathione metabolism.
- 110 candidate genes potentially related to KBD were discovered.
Conclusions:
- The identified 110 candidate genes may play a role in KBD development.
- Apoptosis and oxidative stress-related gene expression changes could serve as early diagnostic and therapeutic biomarkers for KBD.
Related Concept Videos
01:25Beck's Cognitive Therapy
365
Cognitive therapy is a psychological approach designed to address distortions in thinking, which can lead to negative emotions and unrealistic beliefs. These cognitive distortions often influence how individuals interpret and respond to situations, exacerbating emotional distress. Below are some prevalent cognitive distortions, their characteristics, and examples of how they manifest in thought processes.
Arbitrary Inference
Arbitrary inference involves making conclusions without sufficient...
Arbitrary Inference
Arbitrary inference involves making conclusions without sufficient...
365
02:26Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
01:27C4 Pathway and CAM
48.9K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
48.9K
02:18Network Covalent Solids
16.1K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.1K
00:59Gene Therapy
27.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
01:24Other Glycolytic Pathways
858
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
858