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Evaluating the Function of the Foot Core System in the Elderly
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Rational deprescribing in the elderly.

Scott Williams1, Genevieve Miller, Rita Khoury

  • 1Department of Psychiatry and Behavioral Neuroscience, Saint Louis University School, of Medicine, St. Louis, MO 63104 USA.

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|May 3, 2019
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Summary
This summary is machine-generated.

Polypharmacy in elderly patients often leads to harm, with a median of 7 medications prescribed. Deprescribing potentially harmful medications like anticholinergics and opioids can improve geriatric health outcomes.

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Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Clinical Pharmacy

Background:

  • Polypharmacy (≥5 medications) is prevalent in elderly patients, linked to functional decline.
  • Elderly patients receive a median of 7 medications, often causing more harm than benefit.
  • Deprescribing is crucial for mitigating risks associated with polypharmacy in older adults.

Purpose of the Study:

  • To review potentially inappropriate medications for the aging brain.
  • To identify medication classes suitable for deprescribing in the elderly.
  • To synthesize evidence on adverse effects and discontinuation strategies.

Main Methods:

  • Reviewed 2015 Beer's Criteria, STOPP, START, and FORTA list for medication recommendations.
  • Searched PubMed for recent evidence on prescription patterns, adverse effects, and deprescribing in older adults.
  • Focused on five medication classes: anticholinergics, benzodiazepines, antipsychotics, opioids, and proton pump inhibitors.

Main Results:

  • Anticholinergics, benzodiazepines, antipsychotics, and opioids demonstrate significant adverse effects in the elderly.
  • All reviewed medication classes were found to be successfully deprescribable.
  • Evidence supports the discontinuation of these medications in selected geriatric patients.

Conclusions:

  • Polypharmacy elevates risks of adverse drug reactions and hospitalizations in geriatric patients.
  • Rational deprescribing of specific medication classes is a viable strategy to reduce these risks.
  • Deprescribing anticholinergics, benzodiazepines, antipsychotics, opioids, and PPIs can improve geriatric patient safety.