Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An evolutionary perspective on synonymous codon usage in unicellular organisms.

P M Sharp, W H Li

    Journal of Molecular Evolution
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diverse Properties of Electron Forbush Decreases Revealed by the Dark Matter Particle Explorer.

    Physical review letters·2026
    Same author

    [Therapeutic efficacy of retropubic tension-free vaginal tape for female stress urinary incontinence under day surgery mode].

    Zhonghua yi xue za zhi·2025
    Same author

    [Application of 30° reverse trendelenburg combined with semi-prone position in single-port thoracoscopic surgery for lung cancer].

    Zhonghua wai ke za zhi [Chinese journal of surgery]·2025
    Same author

    [Research progress of intestinal-hepatic axis in primary biliary cholangitis].

    Zhonghua nei ke za zhi·2025
    Same author

    [Age-specific distribution characteristics of plantar pressure parameters in healthy children aged 3-12 years].

    Zhonghua er ke za zhi = Chinese journal of pediatrics·2025
    Same author

    [Soft tissue aneurysm bone cysts: a clinicopathological analysis of two cases].

    Zhonghua bing li xue za zhi = Chinese journal of pathology·2025
    Same journal

    Sensing Underwater: Diversifying Selection, Convergent Evolution and Inactivation in Sensory Receptors' Genes of Aquatic Mammals.

    Journal of molecular evolution·2026
    Same journal

    Synonymous Codons as Potential Contributors to Chromatin Stability and Gene Body Methylation in Plants.

    Journal of molecular evolution·2026
    Same journal

    Convergent Functional Genomic Evolution Underlying Repeated Freshwater Colonization in Cetaceans.

    Journal of molecular evolution·2026
    Same journal

    Conditions Enabling the Persistence of Cooperating Synthetase, Ligase, and Mutation-Inhibitor Catalytic Polymers.

    Journal of molecular evolution·2026
    Same journal

    Lineage-Specific Diversification of Nucleoporin Nup98 Genes in Ciliates and Its Evolutionary Implications for the Nuclear Dualism.

    Journal of molecular evolution·2026
    Same journal

    Mitochondrial Genome Evolution: The Influence of Partitioning, Calibration, and Gene Heterogeneity on Pleurodontan Substitution Rates.

    Journal of molecular evolution·2026
    See all related articles

    Synonymous codon usage bias in Escherichia coli genes increases with expression levels, driven by selection. A new index, the Codon Adaptation Index, quantifies this bias, revealing slower evolution in highly biased genes.

    Area of Science:

    • Molecular Biology
    • Evolutionary Biology
    • Genetics

    Background:

    • Synonymous codon usage patterns are influenced by mutation, selection, and genetic drift.
    • Understanding these patterns is crucial for comprehending gene expression and evolution.

    Purpose of the Study:

    • To investigate the relationship between gene expression levels and synonymous codon usage bias in Escherichia coli.
    • To develop a quantitative measure for directional synonymous codon usage bias.

    Main Methods:

    • Analysis of codon usage in 165 Escherichia coli genes.
    • Development and application of the Codon Adaptation Index (CAI).
    • Theoretical modeling to assess the impact of selective differences on codon bias.

    Main Results:

    Related Experiment Videos

    • A positive correlation was observed between gene expression level and codon usage bias.
    • Genes with higher codon bias exhibited slower rates of synonymous substitution.
    • The Codon Adaptation Index effectively quantifies directional codon usage bias.

    Conclusions:

    • Selection plays a significant role in shaping codon usage, particularly in highly expressed genes.
    • The observed codon usage patterns in E. coli can be explained by relatively small selective pressures.
    • The CAI provides a valuable tool for studying codon usage bias and its evolutionary implications.